Fury initially appeared in the World War II combat series Sgt. Fury and his Howling Commandos, as the cigar-chomping NCO who led a racially and ethnically integrated elite unit. The series ran 167 issues (May 1963 – Dec. 1981), though only in reprints after issue #120 (July 1974).
Nick Fury’s aging has been slowed greatly by the Infinity Formula, a serum created by Dr. Berthold Sternberg. Fury was first inoculated with the serum in the 1940s. Fury took the serum annually for many years. Originally Fury had to take the formulae annually or the effects would be reversed allowing his body to reach its actual chronological age.
Nick Fury, Agent of S.H.I.E.L.D. vol. 2 was released in 1989. The series lasted 47 issues (Sept. 1989 – May 1993); its pivotal story arc was “the Deltite Affair”, in which many S.H.I.E.L.D. agents were replaced with Life Model Decoys in a takeover attempt.