The Adventures of Superman was numbered from issue #424 (January 1987) to issue #649 (April 2006), for a total of 228 monthly issues including issue #0 (October 1994) published between issues #516 and #517 as a tie-in to the Zero Hour limited series and issue #1,000,000 (November 1998) as a tie-in to the DC One Million limited series and nine Annuals published between 1987 and 1997.
As of the start of 2002, the integration between the Superman titles became less frequent, and the remaining issues of The Adventures of Superman commonly carried self-contained stories. Issue #600 (March 2002) was a double-sized special featuring Superman combating Lex Luthor.The final issue (#649) was part of a three-part crossover with Superman and Action Comics, an homage to the Earth-2 Superman in the wake of events in the limited series Infinite Crisis.
For its last two years, The Adventures of Superman was written by Greg Rucka. His stories included the villain Ruin, the attempted assassination of Lois Lane and a number of Mister Mxyzptlk appearances.