The underlying difference between this title and the other Spider-Man titles was that Marvel Knights Spider-Man was done with a more mature slant (in style if not content), thus the “Marvel Knights” prefix.
Intended to replace the canceled Spider-Man’s Tangled Web series, Marvel Knights Spider-Man was originally supposed to be written by Kevin Smith, but due to scheduling problems he was replaced by Mark Millar. When Millar completed his year-long story arc, he was followed by writer Reginald Hudlin.
With the consolidation of the Marvel Knights line, Marvel Knights Spider-Man was renamed The Sensational Spider-Man as of issue 23. At this time, Roberto Aguirre-Sacasa took over writing duties on the book.