The second incarnation of the New Mutants debuted in 2003 with an ongoing series of the same name, written by Nunzio DeFilippis and Christina Weir. The series would continue for 13 issues, until June 2004, before being relaunched as New X-Men: Academy X in July 2004, with a new #1.
The series featured a handful of the dozens of mutant teenagers attending the Xavier Institute, as well as their instructors, which included various X-Men as well as former members of the original New Mutants (Karma, Magma, Dani Moonstar, and Wolfsbane).
Another such group, advised by Emma Frost, was known as the Hellions and, like their predecessor, was the arch-rival of the New Mutants. Whereas the original New Mutants series revolved around battles with world-threatening menaces, New Mutants volume 2 focused on the characters’ personal relationships and struggles with controlling their powers.
After “M-Day“, the cataclysmic event that decimated the world’s mutant population, only 27 of the 182 students enrolled at the Xavier Institute retained their powers. The New Mutants and the other training squads were disbanded, and the remaining students were folded into a single junior team, the New X-Men.