Paul Kupperberg laid the groundwork for the new series by writing the John Byrne illustrated Secret Origins Annual #1, published in 1987, which recapped the origins of the two iterations of the Doom Patrol that had existed thus far. In October 1987, DC relaunched Doom Patrol, written by Kupperberg and illustrated by Steve Lightle.
After the first 18 issues (and various crossovers and annuals), Kupperberg was replaced by Grant Morrison, starting with issue #19. Kupperberg agreed to help Morrison by writing out characters Morrison did not want to use: Celsius and Scott Fischer died before issue #18—Celsius was killed in an explosion in DC Comics’ “Invasion!” event, and Scott Fischer (already suffering from a recurrence of childhood leukemia) was the only known active superhero casualty of the Dominators‘ gene-bomb (also in “Invasion!”); Karma had left the team as he was still on the run from the law (he became a member of the Suicide Squad and died on his first mission with them in the “War of the Gods” crossover event); the Negative Spirit left Negative Woman’s body; and Lodestone plunged into a coma, where she would remain for the first half of Morrison’s run on the book. Tempest gave up fieldwork to become the team’s physician. Conversely, Morrison picked up a throw-away character from DP #14, who was slipped into the art on the last page of #18 to set up Morrison’s use: Dorothy Spinner is an ape-faced girl with powerful “imaginary friends.” Morrison also substantially retooled Negative Man: Larry Trainor (revealed to be alive in the Kupperburg run, as a prisoner of an underground society but now powerless) is forcibly merged with the Negative Spirit (now a cosmic entity) and a black doctor named Dr. Eleanor Poole, to create a transgender transracial gestalt entity known as Rebis. The new writer introduced some new characters to the team, including the multiple personality-afflicted Crazy Jane; and sentient roadway Danny the Street.