The series was launched with an April 1985 cover dated issue by writer Louise Simonson and penciller Greg LaRocque and featured the return of Spider-Man’s alien black costume, which attempted to rebond with Peter Parker. Peter managed to rid himself of the costume again using church bells and the alien was presumed to have died after that. The first issue featured a cover painting by artist Charles Vess.
In issue #18 (September 1986), Peter Parker is pushed in front of an oncoming train. He thinks to himself that this should not have happened, as his spider-sense would have warned him of the danger. Writer David Michelinie has said that he wrote this as the first “teaser” appearance of the characterVenom, whom he was planning to introduce at a later date. Venom is an amalgam of reporter Eddie Brock and the alien costume. The costume could nullify Spider-Man’s spider-sense, and this was the first clue of a puzzle that Michelinie was planning to weave to introduce Venom.
Web of Spider-Man Annual #2 (1986) featured stories drawn by Arthur Adams and Mike Mignola. A followup to the Spider-Man vs. Wolverine one-shot appeared in issue #29. The “Kraven’s Last Hunt” storyline by writer J.M. DeMatteis and artists Mike Zeck and Bob McLeod began in issue #31 (October 1987).